Simply adding more milligrams of an enzyme does not necessarily increase the product's potency. When choosing an enzyme blend, look carefully for the activity rating rather than the milligrams per serving, which only indicates the individual components of the blend by their weight as opposed to their strength.
No serious or adverse side effects have been reported from taking systemic enzymes. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. Even after prolonged use at high dosages, enzymes are more easily tolerated in the body than other dietary supplements like Vitamin C or E. If you are taking prescription blood-thinning medication, you should consult your physician before taking a systemic enzyme formula.